Sandoz’s TB Combination Drug 4D and 4D Plus Recalled Due to Inappropriate Dosage on the Strips

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Sandoz’s TB Combination Drug 4D and 4D Plus Recalled Due to Inappropriate Dosage on the Strips

Nov 16th 2013, 06:09

The Maharashtra FDA received reports that strips of pharma major, Sandoz’s TB combination drug, 4D, sold across six states carried the wrong dosage.
On investigation, FDA inspectors found that a more powerful version of the TB drug called 4D plus also carried the wrong dosage. The FDA has ordered the suspension of the sale of drugs 4D and 4D Plus in the state and also alerted the other states where the drug is marketed.

This information to the FDA in Maharashtra was passed on by a South Mumbai Doctor who had noticed the wrong dosage on some strips that one of his patients had bought from a pharmacy in Cumballa Hill.

The patient had come to him after falling extremely sick with bouts of vomiting as he had consumed five such strips.

Consuming drugs in wrong dosages is extremely dangerous. Not only does it render the drug ineffective, such inappropriate dosages can be one of the reasons for the TB bacterium developing great resistance to antibiotics.

Source: Medindia

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Protein-rich Breakfast Helps Curb Appetite

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Protein-rich Breakfast Helps Curb Appetite

Nov 16th 2013, 06:09

In 18-55-year-old women, eating protein-rich breakfast can help curb hunger throughout the morning, reveals study.
“Eating a breakfast rich in protein significantly improves appetite control and may help women to avoid overeating later in the day,” Kevin C. Maki, principal investigator of the study and a research scientist with Biofortis Clinical Research, a Merieux NutriSciences company, said.

All of the breakfast meals contained approximately 300 calories and similar quantities of fat and fiber. The protein-rich breakfast bowls contained 30 to 39 grams of protein.

Participants completed questionnaires to rate aspects of appetite – such as hunger, fullness, and desire to eat- before breakfast and at 30 minute intervals between breakfast and lunch. A standard lunch meal of tortellini and sauce was served and subjects were asked to eat until comfortably full.

Study participants had improved appetite ratings (lower hunger, more fullness, less desire to eat) throughout the morning after eating each protein-rich breakfast, and also ate fewer calories at lunch, compared with the low-protein breakfast and breakfast skipping (water only).

The study was presented at The Obesity Society’s annual scientific meeting in Atlanta.

Source: ANI

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New 3-year BSc Community Health Programme Gets Government Approval

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New 3-year BSc Community Health Programme Gets Government Approval

Nov 16th 2013, 06:09

The main purpose of creating a new cadre of health professionals in rural areas is because many doctors were not willing to serve in these areas.

According to The Health Minister Ghulam Nabi Azad, the proposed course is likely to be introduced in the states that are willing to adopt it from academic 2013-14. This new cadre of health professionals in community health programmes will boost the rural medicare infrastructure in the country.

This course will be a three-and-a -half-year Bachelor of Rural Healthcare course, BSc (Community Health), and those that successfully complete this course can seek employment as Community Health Officers (CHOs) in rural India.

Source: Medindia

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In African-American Children, Researchers Identify First Genetic Mutations Linked to Atopic Dermatitis

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In African-American Children, Researchers Identify First Genetic Mutations Linked to Atopic Dermatitis

Nov 15th 2013, 19:03

A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss-of-function mutations to Filaggrin-2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children. The study, the first report to deduce the mechanism responsible for the persistent form of the condition in African American children, was published in the Journal of Allergy and Clinical Immunology.

Nearly half of people with atopic dermatitis in the United States are African-American children. Previous studies have shown than those of African descent do not usually carry a mutation to the filaggrin gene (FLG) that has been associated with the risk of onset and persistence of AD in those of European and Asian ancestry.

“This finding helps confirm that skin barrier proteins are important in Atopic Dermatitis for people of all ancestries,” said lead study author David Margolis, MD, PhD, professor of Dermatology and Epidemiology. “It could also lead to a way to determine which children are most likely to have persistent flare ups throughout their lives.”

The team evaluated DNA from 299 African American children, none of whom had experienced skin free of symptoms of AD while not on medication in the previous 6 months. Within the group, researchers discovered that children with either one of two FLG2 mutations – rs12568784 or rs16833974 – were more than 50 percent more likely to have persistent AD than those without the mutations.

Future research will work to better understand mutations of FLG2 and determine if they result in functional changes to the FLG2 protein. In addition, the team is continuing research into mechanisms that may turn off the immune response to irritants that pass through the dysfunctional skin barrier and incite the inflammatory response seen in AD.

Source: Eurekalert

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Study Finds Increase in Number Of Nail Gun Injuries Among Young Men

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Study Finds Increase in Number Of Nail Gun Injuries Among Young Men

Nov 15th 2013, 19:03

Writing in the latest Early View issue of Emergency Medicine Australasia, the journal of the Australasian College for Emergency Medicine, Dr James Ling, Dr Natalie Ong, and Dr John North, all from Brisbane’s Princess Alexandra Hospital, said nail guns are commonly used in the building and construction industry because they increase productivity and are technically easy to operate.

However, there has been an increase in the frequency of nail gun-associated injuries, especially in work-related settings.

Public consumers are also at risk of injury, the researchers said.

A previous study showed a three times increase of ED presentations from consumer-related nail gun injuries from 1991 to 2005, which coincided with the availability of pneumatic nail guns to the general public.

In the present study, only four cases (4.6%) were sustained in a non-work-related setting.

Nail gun injuries result in a significant loss of productivity, as well as having a significant financial cost.

Information obtained from the Queensland Employee Injury Data Base shows an average of 81 workers’ compensation claims for nail gun injuries each year over the past five years in Queensland.

Each case subsequently resulted in an average of 15 days off work.

“Whilst nail gun injuries involving the skull, chest and abdomen have been reported, the vast majority of injuries occur to the upper and lower limbs.”

Nail gun injuries most often occur in a contaminated environment and each nail can contain metal barbs or may be coated with polymer or plastic which can become embedded in the wound.

Also, the nail may potentially be discharged into the body with a significant kinetic energy causing marked soft tissue damage.

Potential complications of nail gun injuries are direct damage to soft tissues, tendons, and bones and can result in infections and septic arthritis.

Out of 87 cases identified in this study, which was conducted between January 2007 and July 2012, 58% underwent surgery, 32% were treated solely in the emergency department, and 10% were transferred to a private facility.

At the time of operation, 14% of cases had tendon, joint or neurovascular involvement and 20% had retained foreign material.

The researchers said surgery for such injuries is generally short and safe, involving removal of embedded material, repair of structural damage and a sterile washout.

Source: Eurekalert

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Study: Regardless of Diabetes Status APOL1 Gene Speeds Kidney Disease Progression and Failure in Blacks

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Study: Regardless of Diabetes Status APOL1 Gene Speeds Kidney Disease Progression and Failure in Blacks

Nov 15th 2013, 19:03

The findings, published in conjunction with a presentation at the American Society of Nephrology annual meeting, come from the two largest prospective National Institutes of Health-funded study cohorts of nearly 5,000 individuals with kidney disease: the African-American Study of Kidney Disease and Hypertension (AASK) and the Chronic Renal Insufficiency Cohort (CRIC) study.

Those studies involve institutions from across the country, including the Perelman School of Medicine at the University of Pennsylvania, which houses the Scientific and Data Coordinating Center (SDCC) for the CRIC study, led by Harold I. Feldman, MD, MSCE who also chairs the study’s national Steering Committee.

Dr. Feldman, director of Penn’s Center for Clinical Epidemiology and Biostatistics (CCEB) and chair of its Department of Biostatistics and Epidemiology (DBE) and Amanda H. Anderson, PhD, MPH, assistant professor of Epidemiology in the DBE, are co-authors.

Past studies have found that APOL1 risk variants are associated with a 40 percent increased risk of CKD in African Americans compared to whites. Many, however, focused on people without diabetes. And for those that did focus on diabetes, the findings were inconsistent.

“This was a surprising finding for the group that helps answer another big piece of the puzzle,” said Anderson. “In previous literature, there has been more of a definitive picture of blacks without diabetes, but here we demonstrated that APOL1 gene variants also play a role in the development of kidney failure in those with diabetes.” Such information helps researchers better understand why African-Americans are four times more likely to develop kidney failure than whites, regardless of the cause of failure.

It also helps explain, in part, the faster progression toward kidney failure observed in blacks with CKD, she added.

In the AASK study, which enrolled only African Americans, kidney failure occurred in 58 percent of participants in the APOL1 risk group and 37 percent in the APOL1 non-risk group.

In the CRIC study, kidney function decline was greater among African Americans in the APOL1 risk group, but it was similar among African Americans in the APOL1 non-risk group and European Americans.

The findings provide direct evidence that African Americans with established CKD have a faster kidney function decline and increased rates of kidney failure compared with whites, and that APOL1 risk variants increase CKD progression in African Americans.

Senior authors include researchers from University of Maryland School of Medicine, Johns Hopkins Bloomberg School of Public and Georgetown University of School of Medicine.

“Knowing the role of these variants may lead to screening tests and new preventive measures for those at risk, such as earlier treatment,” said Anderson.

The CRIC study, which started over 10 years ago, is a major national research effort�the Perelman School of Medicine leads a thirteen-institution consortium of academic medical centers � making fundamental insights into the epidemiology, management, and outcomes of CKD. It is supported under NIH grant U01DK060990.

Source: Eurekalert

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